The Switzerland international has struggled with fitness issues ever since his arrival at Craven Cottage from Arsenal in the summer of 2010, but did recover to assert himself as a regular under manager Martin Jol last term.
"It’s nice to be back," Senderos told the club's official website. “I've been training with the reserves so that was my second game. I’m really happy, I’m really pleased. The sensations are good.”
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The former Arsenal man did concede, however, that considering the club's good start to the season, it may be difficult for him to retain his place at the heart of Fulham's backline.
"I’m pleased the team is doing well in my absence as well so it’s good," said Senderos. "It’s been a pretty good start and we're really happy with it.
"The team has responded really well and hopefully, for me personally, I can get my chance and grab it and be in the team. I’m available for selection so hopefully I will start again very soon."
The Cottagers are currently ninth in the Premier League table and face Aston Villa in their first fixture after the international break.