This may be just a friendly match being played in neutral territory but both sides will be desperate to record a victory.
United have looked somewhat lethargic in pre-season and a win would be exceptionally timely particularly given their lacklustre showing in drawing 0-0 with Norwegian outfit Valerenga in their last match.
Barca meantime are beginning a new era under Tito Vilanova and a victory over a team of Manchester United's stature would be a massive boost ahead of the start of the La Liga season.
William Hill price the Catalans as clear favourites, offering odds of 5/6 (1.83) on them coming out on top. United meantime can be backed at 5/2 (3.50), while the draw could prove to be an interesting option at 12/5 (3.40).
Though Barca have the recent advantage in the head to head between the two sides, having won their last two competitive meetings (the Champions League finals of 2009 and 2011 respectively), three out of the four matches prior to those showpiece finals ended as draws.
United have drawn two of their three friendlies so far, while last time out Barca managed a 2-2 draw with PSG. The draw therefore becomes an appealing option and the price available offers a chance for some serious profit to be made.
For a value bet, back the ever dangerous Alexis Sanchez to open the scoring at 4/1 (5.00) with the Chilean already showing signs in pre-season that his total of 15 goals in his first full campaign for the Catalans was no fluke.
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Phil Kitromilides is a sports broadcaster working on radio and TV in London and Madrid. You can also follow Phil on Twitter.